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An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis
Importantly, these self-reacting copper and sulfur redoxomes also interact with each other through the prominent chelation of Cu(I) by thiols of either the antioxidant copper chaperone protein Atox1 or GSH [63, 142, 160,161,162]
This thiol group is reactive and can donate a hydrogen atom to neutralize free radicals and other reactive oxygen species, thereby protecting cells from oxidative stress
Indirectly, GHK-Cu upregulates the expression of key antioxidant enzymes including superoxide dismutase, catalase, and glutathione peroxidase